Applications of comparative genomics in the surveillance of bacterial resistance
DOI:
https://doi.org/10.56183/iberojhr.v5i1.763Palavras-chave:
Comparative genomics, Bacterial resistance, Bioinformatics, Epidemiological surveillance.Resumo
In recent decades, bacterial resistance to antibiotics has become one of the greatest challenges to global public health, as it could cause 10 million deaths annually by 2050 if effective control measures are not implemented immediately. In this context, there is a need for accurate, rapid tools to monitor, understand, and combat the problem. Its application in surveillance has revolutionized the way bacterial resistance is monitored through the analysis of whole genome sequences. A systematic review was conducted to provide a detailed analysis based on the available scientific evidence. The search was conducted in recognized databases such as Scielo , PubMed, Scopus, and Google Scholar, focusing on scientific articles published in English, Portuguese, and Spanish. Comparative studies analyzing genomics were included. The articles were critically appraised to extract relevant data on the applications of comparative genomics in bacterial resistance surveillance. The data obtained were analyzed using an evidence matrix. Finally, it is important to note that their integration into health systems strengthens outbreak response capacity and helps create clearer and more useful rules for proper antibiotic use. Furthermore, their combination with bioinformatics tools and global genomic databases has enabled the development of collaborative international data surveillance networks, which are essential for responding to health problems.
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Copyright (c) 2025 Carlos Fabian Argotti Zumbana, Rodrigo Daniel Argotti Zumbana, Grace Pamela López Pérez, Nathaly Michelle Sánchez Guarnizo, María Salome Argotti Zumbana
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